实验室主任研究方向一：疾病机制研究方向二：成像示踪研究方向三：动物模型研究方向四：临床转化分子影像中心PI列表平台支持团队

姓名：李曼

职称： 研究员
电话：13727082351
电子邮件：liman26@mail.sysu.edu.cn
通讯地址： 珠海市香洲区梅华东路52号中山大学附属第五医院分子影像中心

学历和工作经历

1. 教育经历

2011/08-2015/05, 约翰斯霍普金斯大学, 流行病学, 博士, 导师: Linda Kao

2005/08-2007/05, 爱达荷大学, 统计学, 硕士, 导师: Stephen Lee

2001/09-2005/06, 南京农业大学, 计算机科学与技术, 学士

2. 科研与学术工作经历

2019-9-至今, 中山大学附属第五医院, 研究员

2016/07-2019/08, 犹他大学, 肾病与高血压科, 助理教授

2007/09-2011/05, 约翰斯霍普金斯大学, 流行病学, 研究助理

研究方向

1. 肾脏功能全基因组关联研究

2. 精准医疗与大数据

3. 临床研究中的生物统计学方法

承担科研项目情况

国家自然科学基金青年科学基金项目，82000628，肾小球滤过率相关基因中罕见外显子突变促进慢性肾脏病进展的研究，2021/01-2023/12，主持

校内基金，中山大学“百人计划”，2019/09-2021-12，主持

代表性成果

1. Wuttke M^# , Li Y^# , Li M^#, Sieber KB^# , Feitosa MF^# , Gorski M^# , Tin A, Wang L, Chu AY, Hoppmann A et al. A catalog of genetic loci associated with kidney function from analyses of a million individuals. Nat Genet, 2019, 51, 957-972.

2. Li M^#, Li Y^# , Weeks O^# , Mijatovic V, Teumer A, Huffman JE, Tromp G, Fuchsberger C, Gorski M, Lyytikäinen LP et al. SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function. J Am Soc Nephrol, 2017, 28, 981-994.

3. Pattaro C^# , Teumer A^# , Gorski M^# , ChuAY^# , Li M^#（, Mijatovic V# , Garnaas M, Tin A, Sorice R, Li Y et al. Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nat Commun, 2016, 7, 10023.

4. Agarwal, A.*, Cheung, A.K., Ma, J., Cho, M., Li, M*. Effect of baseline kidney function on the risk of recurrent stroke and on effects of intensive blood pressure control in patients with previous lacunar stroke: a post hoc analysis of the SPS3 trial (Secondary Prevention of Small Subcortical Strokes. J Am Heart Assoc. 2019;8:e013098.

5. Hunter-Zinck, H ^# , Shi, Y ^# , Li, M^#, Gorman, B.R. ^# , Ji, S. ^# , Sun, N. ^# , Webster, T., Liem, A., Hsieh, P., Devineni, P., Karnam, P., Gong, X., Radhakrishnan, L., Schmidt, J., Assimes, T.L., Huang, J., Pan, C., Humphries, D., Brophy, M., Moser, J., Muralidhar, S., Huang, G.D., Przygodzki, R., Concato, J., Gaziano, J.M., Gelernter, J., O'Donnell, C.J., Hauser, E.R., Zhao, H., O'Leary, T.J., VA Million Veteran Program, Tsao, P.S., Pyarajan, S. Genotyping array design and data quality control in the Million Veteran Program. Am J Hum Genet. 2020 Apr 2:S0002-9297(20)30084-7.

6. Loomis Stephanie J^# ; Li Man^# ; Maruthur Nisa M; Baldridge Abigail S; North Kari E; Mei Hao; Morrison Alanna; Carson April P; Pankow James S; Boerwinkle Eric; Scharpf Robert; Rasmussen Torvik Laura J; Coresh Josef; Duggal Priya; Koettgen Anna; Selvin Elizabeth* ; Genome-Wide Association Study of Serum Fructosamine and Glycated Albumin in Adults Without Diagnosed Diabetes: Results From the Atherosclerosis Risk in Communities Study , Diabetes, 2018, 67(8):1684-1696.

7. Mingxing Huang* , Man Li* , Fei Xiao* , Pengfei Pang*, Jiabi Liang* , Tiantian Tang* , Duanqing Pei^# , Lin Tian^# , Jinyu Xia^#, Shanping Jiang^# , Nanshan Zhong^#, Hong Shan^#; Preliminary Evidence from a Multicenter Prospective Observational Study of the Safety and Efficacy of Chloroquine for the Treatment of COVID-19, National Science Review, Volume 7, Issue 9, September 2020, Pages 1428–1436.

8. Mingxing Huang, Tiantian Tang, Pengfei Pang, Man Li ,Ruolan Ma, Duanqing Pei^#, Jinyu Xia^#, Shanping Jiang^# , Hong Shan^#; Treating COVID-19 with Chloroquine，J Mol Cell Biol. 2020 May 18; 12(4):322-325.