姓名：阳新明
职称：副研究员 电话：13418076584 电子邮件： yangxm57@mail.sysu.edu.cn 通讯地址： 珠海市梅华东路52号中山大学附属第五医院分子影像中心
职称：副研究员 电话：13418076584 电子邮件： yangxm57@mail.sysu.edu.cn 通讯地址： 珠海市梅华东路52号中山大学附属第五医院分子影像中心
2004/09-2008/07，中山大学生命科学学院，理学学士
2010/09-2015/12，香港大学化学系，博士
2016/01-2018/12，香港大学化学系，博士后
2019/02-2020/08，德国马普感染生物学研究所，博士后
2020/10-至今，中山大学附属第五医院分子影像中心，副研究员
研究方向着重于病原细菌的致病因子及其与宿主细胞天然免疫系统的相互作用。目前研究团队结合无机生物化学，微生物学，免疫学等学科技术手段，运用类器官感染模型，研究幽门螺旋杆菌利用胆固醇糖基转移酶(cholesteryl glycosyltransferase, CGT) 操控宿主细胞的脂类代谢，从而阻断I型干扰素通路的机制。另外研究革兰氏阴性菌的关键代谢中间产物如何调节宿主细胞天然免疫系统，影响肠道上皮稳态，探索其在炎症性肠道疾病（Inflammatory bowel disease, IBD）中扮演的角色。
中山大学“百人计划”科研项目, 2020-2023,主持
1. H Wang, X Yang, M Wang, M Hu, X Xu, A Yan, Q Hao, H Li, H Sun, Atomic differentiation of silver binding preference in protein targets: Escherichia coli malate dehydrogenase as a paradigm. Chemical Science 11 (43), 11714-11719 (2020)
2. H Wang, Y Wang, X Yang, H Li, J Wang, H Sun, Predicting disease-associated mutation of metal-binding sites in proteins using a deep learning approach. M Koohi-Moghadam, Nature Machine Intelligence 1 (12), 561-567 (2019)
3. H Wang, A Yan, Z Liu, X Yang, Z Xu, Y Wang, R Wang, M Koohi-Moghadam, L Hu, W Xia, H Tang, Y Wang, H Li, H Sun, Deciphering molecular mechanism of silver by integrated omic approaches enables enhancing its antimicrobial efficacy in E. coli. PLOS Biology 17 (6), e3000292 (2019)
4. H Wang, M Wang, X Yang, X Xu, Q Hao, A Yan, M Hu, R Lobinski, H Li, H Sun, Antimicrobial silver targets glyceraldehyde-3-phosphate dehydrogenase in glycolysis of E. coli. Chemical science 10 (30), 7193-7199 (2019)
5. X Yang, M Koohi-Moghadam, R Wang, YY Chang, PCY Woo, J Wang, H Li, H Sun, Metallochaperone UreG serves as a new target for design of urease inhibitor: A novel strategy for development of antimicrobials. PLOS Biology 16 (1), e2003887 (2018)
6. X Yang, H Li, TP Lai, H Sun, UreE-UreG complex facilitates nickel transfer and preactivates GTPase of UreG in Helicobacter pylori. Journal of Biological Chemistry 290 (20), 12474-12485 (2015)
7. X Yang, H Li, T Cheng, W Xia, YT Lai, H Sun, Nickel translocation between metallochaperones HypA and UreE in Helicobacter pylori. Metallomics 6 (9), 1731-1736 (2014)
8. W Xia, H Li, X Yang, KB Wong, H Sun, Metallo-GTPase HypB from Helicobacter pylori and its interaction with nickel chaperone protein HypA. Journal of Biological Chemistry 287 (9), 6753-6763 (2012)
