2017/08-至今，中山大学，附属第五医院，副研究员

2016/07-2017/07，新加坡国立大学，资深博士后

2012/02-2016/06，新加坡国立大学，博士后
2006/01-2011/11，南洋理工大学（新加坡），博士

1. 感染与固有免疫

2. 微生物菌群与肿瘤

3. Hippo信号通路

在研科研项目：

1. 国家自然科学基金，面上项目，82170029，肺泡II型上皮细胞YAP/TGFβ2/CTGF通路参与哮喘终末气道纤维化的作用机制研究 2022/01-2025/12
2. 国家自然科学基金，面上项目，81870019 ，CD151在鼻病毒诱导型哮喘气道重塑中的作用及分子机制研究，2019/01-2022/12，主持

3. 中山大学“百人计划”科研启动项目，免疫学，2017/09-2020/08，主持

已完成科研项目：

1 广东省自然科学基金，自由申请项目，2018A030313554 ，RV16鼻病毒感染气道上皮细胞激活成纤维细胞的分子机制及其在慢性气道炎症疾病中的病理作用研究，2018/05-2021/04，主持
2. 广州市产学研协同创新重大专项民生科技研究，TSLP-Hippo/YAP通路介导成纤维细胞转分化在重症哮喘气道重塑中的作用，2017/01-2019/12，参与

1. Yuanyang Tan^#, Yongkang Qiao^#, Zhuanggui Chen, Jing Liu, Yanrong Guo, Thai Tran, Kai Sen Tan, De-Yun Wang*, Yan Yan*. FGF2, an immunomodulatory factor in asthma and chronic obstructive pulmonary disease (COPD). Front Cell Dev Biol, 2020,8:223.

2. Zhaoni Wang^#, Ruonan Su^#, Biyun Yang, Kexin Yang, Lifen Yang, Yan Yan*, Zhuanggui Chen*.Potential role of cellular senescence in asthma. Front Cell Dev Biol, 2020,8:59.

3. Yan-Rong Guo ^#, Qing-Dong Cao ^#, Zhong-Si Hong ^#, Yuan-Yang Tan, Shou-Deng Chen, Hong-Jun Jin, Kai Sen Tan, De-Yun Wang*, Yan Yan*. The origin, transmission and clinical therapies on coronavirus disease 2019 (COVID-19) outbreak - an update on the status. Mil Med Res, 2020 Mar 13;7(1):11.

4. Sisi Kang, Mei Yang, Zhongsi Hong, Liping Zhang, Zhaoxia Huang, Xiaoxue Chen, Suhua He, Ziliang Zhou, Zhechong Zhou, Qiuyue Chen, Yan Yan, Changsheng Zhang, Hong Shan*, Shoudeng Chen*. Crystal structure of SARS-CoV-2 nucleocapsid protein RNA binding domain reveals potental unique drug targeting sites. Acta Pharm Sin B, 2020 Apr 20 doi: 10.1016/j.apsb.2020.04.009

5. Kai Sen Tan^#, Anand Kumar Andiappan^#, Bernett Lee, Yan Yan, Jing liu, See Aik Tang, Josephine Lum, Yew Kwang Ong, Kim Thye Thong, Hui Fang Lim, Hyung Won Choi, Olaf Rotzschke, Vincent T Chow*, De Yun Wang*. RNA sequencing of H3N2 influenza virus-infected human nasal epithelial cells from multiple subjects reveals molecular pathways associated with tissue injury and complications. Cells, 2019 Aug 27;8(9). pii: E986.

6. Kai Sen Tan^#, Yan Yan^#, Wai Ling Hiromi Koh^#, Liang Li, Hyungwon Choi, Thai Tran, Richard Sugrue, De Yun Wang*, Vincent T Chow*. Comparative transcriptomic and metagenomic analyses of influenza virus-infected nasal epithelial cells from multiple individuals reveal specific nasal-initiated signatures. Front Microbiol, 2018. 9:2685

7. Huong Tra ^#, Yan Yan^#, Muhammad Jumat, Jing Liu, Boon Huan Tan, De Yun Wang, Richard Sugrue*. A sustained antiviral host response in respiratory syncytial virus infected human nasal epithelium does not prevent virus transmission. Virology, 2018. 521, 22-32.

8. Yongkang Qiao^#, Yan Yan^#, Kai Sen Tan^#, Sheryl SL Tan^#, Ju Ee Seet, Thiruma Valavan Arumugam, Vincent T Chow, De-Yun Wang*, Thai Tran*. CD151, a novel host factor of nuclear export signaling in influenza virus infection. J Allergy Clin Immunol, 2018. 141(5), 1799-1817.

9. Kai Sen Tan ^#, Hsiao Hui Ong ^#, Yan Yan^#, Jing Liu ^#, Yew Kwang Ong, Kim Thye Thong, Hyung Wong Choi, De-Yun Wang*,Vincent T Chow*. In vitro model of fully differentiated human nasal epithelial cells infected with rhinovirus reveals epithelium-initiated immune responses. J Infect Dis, 2018, 217:906-915.

10. Yan Yan^#, Kai Sen Tan ^#, Chunwei Li, Thai Tran, Siew Shuen Chao, Richard J Sugrue, Li Shi, Vincent T Chow *, De-Yun Wang *. Human nasal epithelial cells derived from multiple individuals exhibit differential responses to H3N2 influenza virus infection in vitro. J Allergy Clin Immunol, 2016,138(1):276-281.