金红军，分子影像中心研究员，博士生导师。1990至1994年在兰州大学放射化学专业学习，获理学学士学位；1994至1997年在北京中医药大学中医临床专业学习，获医学学士学位；1997年起在北京吉比爱生物技术公司任酶联检测研助；1999年10月在美国Louisville大学医学院Bhatnagar教授组任研助；2000年10月在美国Iowa大学放射病理与口腔肿瘤系Kurago教授组任研助；2002年8月获全奖资助在美国Texas A&M大学学习，2007年12月获生化专业博士学位。2008至2012年在美国PNNL国家实验室Zangar教授组接受分子标志物博后训练；2012年3月起在美国St. Louis华盛顿大学放射系Tu教授组接受分子影像博后训练，2013年起任该研究所放射医学讲师。2017年10月份起全职加入中山大学附属第五医院。首次完成了多个PET正电子药物的设计、研发以及临床转化，比如18F/11C标记的σ1受体、乙酰胆碱囊泡转运体（VAChT）、α-突触蛋白、PDE10A酶，S1PR1/2受体和P2X7受体的小分子探针。同时研发了68Ga/64Cu/89Zr标记的抗体或者多肽生物大分子的分子探针。其中VAChT探针18F-VAT已在华盛顿大学获FDA许可开展人体临床实验（eIND #125,627）。主持或者参与了共计14项科研基金项目，发表学术论文60余篇，授权国内外专利7项。主要学术兼职：中国核学会放射药物分会理事；广东省药学会核药专委会副主委；广东省核学会核药学分会副主委；广东省放射医学分会分子影像学组组长；中国药理学杂志 （Acta Pharmacologica Sina）、BMC Biomedical Imaging 评委等。

正电子放射药物和PET分子影像学

在研科研项目：

1. 中山大学”百人计划”人才启动项目, 2017/10-2022/09, 主持

2. 珠海市“新型冠状病毒感染防治”应急科技攻关专项, “特异靶向新冠(SARS-CoV-S-蛋白的PET分子影像探针”, 2020/08-2021/09，主持

3. 国家自然科学基金面上项目: “F-18 标记靶向 P2X7受体的PET小分子探针及其在阿尔茨海默病早期诊断中的基础研究”, 2018/10-2022/9，主持

4. 中大五院研究者发起临床研究项目（IIT）奖评,A类资助,“单中心、开放、前瞻性评估18F-FDG PET/CT动态显像及基因检测在探查非小细胞肺癌癌转移灶中的诊断意义”，2020/10-2021/09，主持

5. 国家重点研发计划“精准医学研究”专项, “基于实时高空间分辨率和多模态图像融合技术的食管癌临床诊疗方案”, 2018/09-2021/12, 核心参与

6. 广东省脑科学与类脑研究”重大科技专项-“帕金森病早诊早治的新靶点和新方法”，2019/01-2022/12, 核心参与

已完成科研项目：

1. 美国NIH R01 NS 075527，06/2012-5/2017，针对乙酰胆碱囊泡转运体（VAChT）PET的分子探针，核心参与

2. 美国NIH R21 MH 092797，02/2012-12/2017，研发针对PDE10A酶的PET分子探针，核心参与

3. 美国Michael J. Fox私人基金会资助，联合攻关项目，10/2012-03/2017, 研发针对α-突触蛋白用于帕金森疾病早期诊断，核心参与

4. 美国能源部国家实验室专项基金，DOE/LDRD，10/2010-02/2012，利用噬菌体展示技术优化超级还原酶用于环境生物废物降解，主持

1. Xian J^#, Pei X^#, Lu W, Zhong H, Lin Y, Jin H*, Su Z.*, The clinical value of bedside ultrasound in predicting the severity of coronavirus disease-19 (COVID-19), Anal Transl Med 2021, 9(4): 336, PMID: 33708963

2. Pei X^#, Wang X^#, Xian J^#, Mi J, Gao J, Li X, Li Z, Yang M, Bi L, Yan Y, Lv W*, Jin H*, Metformin and oxyphotodynamic therapy as a novel treatment approach for triple-negative breast cancer, Anal Transl Med, 2020, 8(18):1138, PMID: 32546966

3. Yang M^#, Lin Z^#, Xu Z^#, Li D, Lv W, Yang S, Liu Y, Cao Y, Cao Q, Jin H*, Influx rate constant of18F-FDG increases in metastatic lymph nodes of non-small cell lung cancer patients, Eur J Nuc Med Mole Imag, 2020, 47(5):1198-1208, PMID: 31974680

4. Chen X, Li D, Cao Y, Gao J, Jin H*, Shan H*, Early Therapeutic Vaccination Prediction of Hepatocellular Carcinoma via Imaging OX40 Mediated Tumor Infiltrating Lymphocytes. Mole Pharm, 2019,16(10):4252-4259, PMID: 31454248

5. Li Yijie, Zeng Q, Wu M, Guo Z and Jin H*, Antibiotic Prophylaxis for Transarterial Chemoembolization of Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis, J Mol Genet Med, 2019, 13(1):406-413

6. Li Yijie, Wu M, Zhu W, Huang L, Zeng Q and Jin H*, Are prophylactic antibiotics necessary prior to thyroid and parathyroid surgery for the prevention of surgical site infection? A systematic review and meta-analysis，Am J Trans Med, 2018. 2:86-95

7. Liu H, Jin H, Han J, Yue X, Yang H, Zayed MA, Gropler RJ, Tu Z. Upregulated sphingosine 1-phosphate receptor 1 expression in human and murine atherosclerotic plaques. Mol Imaging Biol, 2018, 20(3):448-456. PMID: 29134505

8. Liu H, Jin H, Luo Z, Yue X, Zhang X, Flores HP, Su Y, Perlmutter JS, Tu Z. In vivo characterization of two 18F-labeled PDE10A PET radioligands in nonhuman primate brains. ACS Chem Neurosci, 2018,9(5):1066-1073. PMID: 29400443

9. Jin H, Han J, Resing D, Liu H, Yue X, Miller RL, Schoch KM, Miller TM, Perlmutter JS, Egan TM, Tu Z. Synthesis and in vitro characterization of a P2X7 radioligand [123I]TZ6019 and its response to neuroinflammation in a mouse model of Alzheimer’s disease. Eur J Pharmacol, 2018, 820:8-17. PMID: 29225193

10. Jin H, Yue X, Liu H, Han J, Flores HP, Su Y, Parsons SM, Perlmutter JS, Tu Z. Kinetic modeling of [18F]VAT, a novel radioligand for positron emission tomography imaging vesicular acetylcholine transporter in non-human primate brain. J Neurochem, 2018,144(6):791-804. PMID: 29315563

11. Liu H, Jin H, Yue X, Han J, Baum P, Abendschein DR, Tu Z. PET study of sphingosine-1-phosphate receptor 1 expression in response to vascular inflammation in a rat model of carotid injury, Mol Imaging, 2017 (16): 1-7, PMID: 28654378

12. Jin H, Yang H, Liu H, Zhang Y, Zhang X, Rosenberg A, Liu Y, Lapi S, Tu Z. A Promising carbon-11 labeled sphingosine-1-phosphate receptor specific PET tracer for imaging vascular injury, J Nucl Cardiol，2017, 24(2):558-570 PMID:26843200

13. Yue X, Jin H, Luo Z, Liu H, Zhang X, McSpaddenED, Tian L, Flores HP, Perlmutter JS, Parsons SM, Tu Z. Chiral resolution of serial potent and selective σ 1 ligands and biological evaluation of (−)-[18F] TZ3108 in rodent and the nonhuman primate brain, Bioorg Med Chem, 2017, 25(4): 1533-1542, PMID: 28129990

14. Jin H, Zhang X, Yue X, Liu H, Li J, Flores HP, Su Y, Perlmutter JS, Tu Z. Kinetics modeling and occupancy studies of a novel C-11 PET tracer for VAChT in nonhuman primates, Nucl Med Biol, 2016, 43 (2): 131–139 PMID: 26872437

15. Liu H, Jin H, Yue X, Luo Z, Liu C, Rosenberg AJ, Tu Z. PET imaging study of S1PR1 expression in a rat model of multiple sclerosis. Mol Imaging Biol, 2016,18(5):724-32.

16. Li J, Zhang X, Jin H, Fan J, Flores HP, Perlmutter JS, Tu Z. Synthesis of fluorine-containing phosphodiesterase 10A (PDE10A) inhibitors and the in vivo evaluation of F-18 labeled PDE10A PET tracers in rodent and nonhuman primate, J Med Chem, 2015, 58(21):8584-600. PMID: 26430878

17. Yue X, Jin H, Liu H, Rosenburg AJ, Klein RS, Tu Z. A potent and selective C-11 labeled PET tracer for imaging sphingosine-1-phosphate receptor 2 in the CNS demonstrates sexually dimorphic expression, Org Biomol Chem, 2015 13(29):7928-39 PMID: 26108234

18. Tu Z, Zhang X, Jin H, Yue X, Padakanti PK, Yu L, Liu H, Flores HP, Kaneshige K, Parsons SM, Perlmutter JS, Synthesis and biological characterization of a promising F-18 PET tracer for vesicular acetylcholine transporter, Bioorg Med Chem, 2015, 23(15):4699-709 PMID: 26138195

19. Liu H, Jin H, Li J, Zhang X, Kaneshige K, Parsons SM, Perlmutter JS, Tu Z. In vitro and ex vivo characterization of (-)-TZ659 as a ligand for imaging the vesicular acetylcholine transporter, Eur J Pharmacol, 2015, 5;752:18-25,PMID: 25678250

20. Liu H, Jin H, Yue X, Zhang X, Yang H, Li J, Flores HP, Su Y, Perlmutter JS, Tu Z. Preclinical evaluation of a promising C-11 labeled PET tracer for imaging phosphodiesterase10A in the brain of living subject, Neuroimage, 2015 (121): 253-262 PMID: 26216275

21. Jin H, Fan J, Zhang X, Li J, Flores HP, Su Y, Perlmutter JS, Tu Z. Radiosynthesis and in vivo evaluation of a novel selective PET ligand, MedChemComm, 2014, 5(11): 1669-1677, PMID:25584182

22. Jin H, Halstrand TS, Daly DS, Matzke MM, Nair P, Bigelow DJ, Pounds JG, Zangar RC. A halotyrosine antibody that detects increased protein modifications in asthma patients, J Immunol Methods, 2014, 403:17-25. PMID:24295867

23. Jin H, Xu M, Padakanti PK, Liu Y, Lapi S, Tu Z. Preclinical evaluation of the novel monoclonal antibody H6-11 for prostate cancer imaging, Mol Pharm, 2013, 10 (10): 3655-3664. PMID:23964702

24. Jin H*, Zhang Y, Buchko GW, Varnum SM, Robinson H, Squier TC, Long PE. Structure determination and functional analysis of a chromate reductase from gluconacetobacterhansenii. PLoS ONE, 2012, 7(8): e42432. PMID:22879982

25. Jin H, Zangar RC. Invited review: High-throughput, multiplexed analysis of 3-nitrotyrosine in individual proteins, John Wiley & Sons Press Inc (ISBN: 9780471140856), Curr Protoc Toxicol, 2012,Chapter 17:Unit 17.15., PMID:22511115

26. Jin H*, Yu Y, Chrisler WB, Xiong Y, Hu D, Lei C. Delivery of microRNA-10b with polylysine nanoparticles for inhibition of breast cancer cell wound healing. Breast Cancer (Auckl), 2012;6:9-19. PMID: 22259248

27. Jin H, Web-Robertson BJ, Peterson ES, Tan R, Bigelow DJ, Scholand MB, Hoid JR, Pounds JG, Zangar RC. Smoking, COPD and 3-nitrotyrosine level of plasma proteins. Environ Health Perspect, 2011, 119(9):1314-20, PMID:21652289

28. Jin H, Ioannis K, Li P, LiWang PJ. Structure and functional studies of the potent anti-HIV chemokine variant P2-RANTES, Proteins, 2010, 78:295-308. PMID:19722264

29. Jin H, Shen X, Baggett BR, Kong X, Liwang PJ. The human CC chemokine MIP-1b dimer is not competent to bind the CCR5 receptor. J Biol Chem, 2007, 282 (38): 27976-27983, PMID:17644519

30. Jin H, Hayes GL, Darbha NS, Meyer E, LiWang PJ. Investigation of CC and CXC chemokine quaternary state mutants. Biochem Biophys Res Commun, 2005, 38(2): 987-99,PMID:16256937

31. Liu S, Jin H, Zacarias A, Srivastava S, Bhatnagar A. Binding of pyridine coenzyme nucleotides to the voltage-sensitive potassium (K+) channel-subunit, J Biol Chem, 2001, 276 (15): 11812- 20. PMID:11278398

1. 珠海市“英才计划”评选，2020年11月获得高层次人才支持计划 “二类人才” 奖

2. 美国心脏核医学会 (ASNC), 2018年度最佳基础科学研究奖

3. 美国核医学与分子影像学会 (SNMMI) , 2017年度Berson-Yalow奖